twoplus fertility

We are making a new fertility treatment that infertile couples can order with a click of a

button to help them conceive at home. Our technology increases the likelihood of pregnancy by guiding significantly higher number of sperms towards the ovum using a proprietary combination of surface features and microenvironment optimization.

The fertility treatments available today, such as in-vitro fertilization (IVF) and intra-uterine

insemination (IUI), are psychologically and financially draining and come with considerable treatment-associated risks. Furthermore, over 25 million women of reproductive age in the US

have limited nearby access to fertility treatment.

High-Level Overview

twoplus fertility is a Singapore-based health technology company that develops an effective, home-use fertility treatment designed to support natural conception for infertile couples. Their flagship product is a patented medical device that guides a significantly higher number of sperm towards the ovum by combining unique surface engineering with optimized microenvironments, increasing the likelihood of pregnancy without the invasiveness, high cost, or psychological burden of traditional fertility treatments like IVF or IUI[1][2]. The company primarily serves couples seeking privacy, convenience, and affordability in their fertility journey, addressing a significant gap for millions of women globally who have limited access to fertility clinics[1].

For an investment firm, twoplus fertility’s mission is to empower 1 million couples to conceive naturally over the next decade by providing accessible, innovative fertility solutions[4]. Their investment philosophy likely centers on health technology innovation with a focus on consumer-facing, home-based medical devices that disrupt traditional clinical models. Key sectors include reproductive health, medical devices, and digital health. Their impact on the startup ecosystem includes pioneering home-based fertility care, reducing barriers to conception, and expanding the market for at-home medical treatments[3][4].

Origin Story

twoplus fertility was founded in 2019 by Prusothman Raja, a medical device innovator experienced in product development and FDA navigation, and Benjamin Tee, a Stanford Biodesign Fellow and serial entrepreneur with a background in biomedical engineering[2][3]. The idea emerged during their Singapore-Stanford Biodesign Fellowship in 2014, inspired by their personal and friends’ struggles with infertility and the limitations of existing treatments like IUI and IVF, which are costly, invasive, and clinic-dependent[3]. They identified that most sperm fail to reach the cervical opening, reducing pregnancy chances, and developed the Sperm Guide device to address this biological challenge with a simple, home-use solution[3]. Early traction includes successful product launches in Singapore, the UK, Malaysia, and the US, with revenue generation and positive customer feedback from couples who conceived after using twoplus products[3][4].

Core Differentiators

• Product Differentiators: Patented device with over 100 iterations, combining surface engineering and microenvironment optimization to enhance sperm transport and survival[1][4].
• Developer Experience: Founders bring deep expertise in medical device innovation, FDA processes, and biodesign innovation, ensuring a scientifically rigorous and user-friendly product[2][3].
• Speed, Pricing, Ease of Use: Home-use, over-the-counter device that is affordable, non-invasive, and easy to use, providing a convenient alternative to clinic-based treatments[1][3].
• Community Ecosystem: Supports couples with expert guidance and emotional support, fostering a community of users who share success stories and reduce stigma around fertility challenges[5][7].

Role in the Broader Tech Landscape

twoplus fertility rides the growing trend of consumer-driven, home-based healthcare solutions empowered by advances in medical device engineering and digital health. The timing is critical as fertility rates decline globally and demand for accessible, affordable fertility care rises, especially in regions with limited clinic access[1][3]. Market forces such as increasing infertility awareness, stigma reduction, and the desire for privacy favor twoplus’s model. By democratizing fertility treatment, twoplus influences the broader ecosystem by challenging traditional clinical paradigms and expanding the fertility care market to include at-home, user-empowered options[1][3][4].

Quick Take & Future Outlook

Looking ahead, twoplus fertility aims to scale its impact by reaching 1 million couples within the next 10 years, expanding geographically and broadening its product portfolio with additional at-home fertility tests and treatments[4][6]. Trends shaping their journey include rising digital health adoption, personalized medicine, and increasing consumer demand for non-invasive reproductive health solutions. Their influence is likely to grow as they continue to validate their technology’s effectiveness and build a trusted brand in fertility care, potentially partnering with clinics and telehealth providers to create hybrid care models[3][6]. This positions twoplus fertility as a transformative player in making fertility care more accessible, affordable, and user-centric, fulfilling their mission to help couples conceive naturally with confidence and support.