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§ Private Profile · San Francisco, CA, USA
Noctrix Health is a technology company.
Noctrix Health, Inc. is made up of a team of medical and industry experts pursuing a common goal: helping people with chronic conditions live better lives through clinically-proven alternatives to pharmaceuticals.
Noctrix Health has raised $124.5M across 4 funding rounds.
Noctrix Health has raised $124.5M in total across 4 funding rounds.
Noctrix Health has raised $124.5M across 4 funding rounds. Most recently, it raised $33.5M Other Equity in September 2025.
| Date | Round | Lead Investors | Other Investors | Status |
|---|---|---|---|---|
| Sep 2, 2025 | $33.5M Venture Round | — | Bluecross Blueshield Venture Partners, Sandbox Clinical Ventures | Announced |
| Aug 1, 2025 | $34M Series U | — | OrbiMed, Sandbox Industries | Announced |
| Jan 16, 2024 | $40M Series C | Michael Sjostrom | Angelini Ventures, Asahi Kasei, Evan Caplan, Resmed, Tracy Pappas | Announced |
| Jan 1, 2021 | $17M Series B | — | Andera Partners, OrbiMed | Announced |
Noctrix Health, Inc. is a medical technology company developing wearable therapeutics using a neurostimulation platform to treat chronic neurological conditions, starting with Restless Legs Syndrome (RLS), the second-largest sleep disorder affecting over 10% of US adults.[1][2][3] The company builds prescription-grade, non-pharmaceutical devices that deliver neuromodulation therapy via wearables, targeting patients experiencing painful tingling and an irresistible urge to move their legs, especially at night, as an alternative to dopaminergic drugs.[1][2][3] It serves RLS patients seeking better sleep and symptom relief, solving the unmet need for safe, effective non-drug options backed by clinical evidence; the FDA granted its therapy Breakthrough Device Designation to speed development and launch.[3] Growth momentum includes incorporation in 2018, a $17M Series B financing in 2021 led by OrbiMed and Treo Ventures, and ongoing clinical trials.[2][3]
Noctrix Health emerged from Stanford University’s Biodesign Innovation Program, where founder Shri Raghunathan, a Purdue- and Stanford-trained engineer expert in neuromodulation and medical devices, identified the critical gap in RLS treatments.[2][3] He partnered with Jonathan Charlesworth, a Princeton- and UCSF-trained neuroscientist focused on evidence-based neurotech solutions.[2] The company incorporated in 2018 with a mission to popularize wearable therapeutics for millions of RLS patients.[2][3] Early traction came from building a team blending medical device veterans, neuroscientists, and consumer electronics engineers, securing global angel and venture backing, and advancing toward FDA milestones.[1][2][3]
Noctrix Health rides the neuromodulation and wearable therapeutics wave, shifting chronic disease management from pills to targeted, non-invasive devices amid rising demand for drug-free options in neurology and sleep disorders.[1][3] Timing aligns with FDA's push for breakthrough innovations and growing RLS awareness (impacting millions globally), fueled by market forces like aging populations, sleep health prioritization post-pandemic, and neuromodulation's expansion beyond Parkinson's to everyday conditions.[2][3] It influences the ecosystem by pioneering scalable wearables, potentially expanding its platform to other neurological issues, validating neurotech for consumer-like adoption, and attracting venture capital to medtech startups.[1][3]
Noctrix Health is poised for commercialization of its RLS device post-FDA breakthrough status, with Series B funds fueling trials, regulatory clearance, and market entry to capture a slice of the massive RLS market.[3] Trends like AI-enhanced neuromodulation, personalized wearables, and non-opioid therapies will propel growth, possibly leading to platform expansions for other sleep or chronic conditions.[1][2] Its influence could evolve from RLS pioneer to broader neurotherapeutics leader, humanizing medtech by blending consumer UX with clinical rigor—echoing its origins in spotting an overlooked patient need at Stanford.[2][3]
Noctrix Health has raised $124.5M in total across 4 funding rounds.
Noctrix Health's investors include BlueCross BlueShield Venture Partners, Sandbox Clinical Ventures, OrbiMed, Sandbox Industries, Michael Sjostrom, Angelini Ventures, Asahi Kasei, Evan Caplan, ResMed, Tracy Pappas, Andera Partners.