Yoneda Labs

Yoneda Labs provides software to help chemists optimise reactions. When chemists make a drug or a material, we help them figure out the best reaction parameters such as temperature, concentration and catalyst.

When Jan was working at chemical labs, he experienced the struggle of spending weeks guessing reaction conditions. We then started experimenting with ML to speed up the process.

Now, as a team of three friends from the University of Cambridge, we’ve spent the last month combining our domain expertise in Computer Science, Machine Learning and Chemistry to develop state of the art models for reaction optimisation.

Although ML is becoming well established in other fields, current chemical models generalise poorly and require lots of programming experience. We make our models easily accessible to chemists in the lab.

Finding the right conditions quickly allows pharmaceutical companies to test more drugs, and finding better optima makes manufacturing process cheaper and more environmentally friendly.

High-Level Overview

Yoneda Labs is a cutting-edge startup founded in 2023 that develops a foundation AI model for chemical manufacturing, specifically targeting the optimization of chemical reactions critical to drug discovery and materials science. Their software helps chemists determine optimal reaction parameters—such as temperature, concentration, and catalysts—significantly reducing trial-and-error experimentation. This results in faster, cheaper, and more environmentally friendly chemical synthesis, directly benefiting pharmaceutical and chemical manufacturing sectors by increasing efficiency and reducing costly failed experiments[1][2][4].

For an investment firm, Yoneda Labs represents a mission-driven company leveraging AI to transform traditional chemical manufacturing processes. Their investment philosophy likely centers on backing deep tech startups that combine machine learning with domain expertise to disrupt established industries. Key sectors include AI, chemical manufacturing, and pharmaceuticals. Yoneda Labs' impact on the startup ecosystem is notable as it pioneers the application of foundation models—previously dominant in NLP and vision—to chemistry, potentially catalyzing a wave of innovation in scientific R&D automation[1][2].

For a portfolio company, Yoneda Labs builds AI-powered software that serves chemists in pharmaceutical and chemical manufacturing industries. It solves the problem of inefficient, costly, and slow reaction optimization by predicting optimal conditions before physical experiments, increasing productivity by an order of magnitude. The company has demonstrated strong growth momentum, raising $4 million in seed funding led by Khosla Ventures and Y Combinator, and is scaling its robotics lab to run hundreds of experiments daily to further train its models[2][3].

---

Origin Story

Yoneda Labs was founded in 2023 by Michal Mgeladze-Arciuch, whose background combines expertise in chemistry and machine learning. The idea emerged from the recognition that while AI had accelerated drug discovery design, chemists synthesizing drugs still relied heavily on manual trial-and-error in wet labs without computational support. This gap inspired the creation of a foundation AI model that could predict reaction outcomes and optimize parameters, reducing waste and accelerating innovation[1][2].

Early traction included generating a proprietary dataset of 20,000 chemical reactions during their Y Combinator program, which enabled training a model that suggested optimal conditions with 95% accuracy in small-scale trials—a significant improvement over industry standards where most experiments fail. This success attracted $4 million in seed funding to expand their robotics capabilities and scale their model training[2][3].

---

Core Differentiators

• Product Differentiators: Yoneda Labs offers the first foundation AI model specifically designed for chemical reaction optimization, covering key organic reactions with a relatively small but high-quality dataset (20,000 data points) to generalize across many scenarios[1][2].

• Developer Experience: Their software integrates advanced machine learning with domain-specific chemical knowledge, providing chemists with actionable predictions that reduce reliance on literature searches and manual experimentation[2][4].

• Speed and Scale: By building a robotics lab capable of running 200 experiments per day—equivalent to the output of 20 full-time chemists—they accelerate data generation and model refinement, enabling rapid iteration and deployment[2].

• Community Ecosystem: Backed by Y Combinator and Khosla Ventures, Yoneda Labs benefits from a strong network of investors and industry partners, positioning it well to influence the chemical manufacturing and pharmaceutical ecosystems[2][3].

---

Role in the Broader Tech Landscape

Yoneda Labs rides the wave of foundation models and AI-driven automation that have transformed fields like natural language processing and computer vision, now applied to chemistry—a traditionally manual and costly domain. The timing is critical as pharmaceutical and chemical industries face pressure to reduce R&D costs and environmental impact while accelerating innovation. Market forces such as increasing AI adoption, demand for sustainable manufacturing, and the rise of computational chemistry favor Yoneda Labs' approach[1][2].

By pioneering a generalizable AI model for chemists, Yoneda Labs is poised to influence the broader ecosystem by enabling more efficient drug discovery and chemical manufacturing workflows, potentially setting new industry standards and inspiring further AI integration in scientific research[1][2].

---

Quick Take & Future Outlook

Yoneda Labs is positioned to become a key player in AI-driven chemical manufacturing, with plans to scale their robotics lab and expand their foundation model to cover more reaction types. Future trends shaping their journey include advances in generative AI, increased automation in labs, and growing demand for sustainable and cost-effective chemical processes.

Their influence may evolve from a niche AI tool to an indispensable platform for chemists worldwide, driving a paradigm shift in how chemical synthesis is approached. This aligns with their mission to multiply chemists' productivity and unlock new possibilities in drug discovery and materials science[2][4].

Yoneda Labs exemplifies the convergence of AI and chemistry, heralding a future where computational models fundamentally reshape chemical manufacturing efficiency and innovation.