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§ Venture Capital · USA
Venture capital firm investing in early-stage digital health & health tech firms, focused on value-based care, consumer health, AI.
Define Ventures is a San Francisco, California-based venture capital firm that invests in early-stage digital health and healthcare technology companies. The firm focuses on seed, Series A, and Series B funding rounds, targeting startups developing solutions in value-based care, consumer-driven healthcare, and artificial intelligence-enhanced clinical care. Operating with a business model that manages capital from limited partners, the firm currently oversees six funds and holds $800 million in assets under management. Define Ventures writes initial checks ranging from $500,000 to $10 million for a portfolio encompassing more than two dozen active companies, including recognizable names such as Hims and Hers, Cohere Health, FOLX Health, Unite Us, and 9amHealth. Recently, the firm released a dedicated investing thesis focused on broader healthcare system transformation through artificial intelligence. The venture capital organization was originally founded by Lynne Chou O'Keefe.
Key people at Define Ventures.
Key people at Define Ventures.
Define Ventures is an early-stage venture capital firm focused on investing in digital health companies that are shaping the future of healthcare through technology and innovation. Their mission centers on partnering with visionary entrepreneurs who combine deep healthcare expertise with a technology-driven mindset to build category-defining companies. They emphasize a principled, partnership-driven approach, leveraging a strong network of healthcare and Silicon Valley experts to accelerate growth and commercial impact in sectors such as enterprise healthcare, value-based care, direct-to-consumer health, and AI-enabled health technologies. Define Ventures plays a significant role in the startup ecosystem by providing capital, strategic guidance, and operational support to early-stage digital health startups, helping them navigate complex healthcare markets and scale effectively[1][2][3].
Founded with the belief that the future of healthcare requires collaboration between innovators and incumbents, Define Ventures has grown to become one of the largest funds dedicated to early-stage health tech, managing approximately $800 million across six funds. The firm was established by partners with deep backgrounds in healthcare and technology, who have built category-defining companies themselves. Their evolution has been marked by a focus on integrating AI and advanced technologies into healthcare, anticipating market needs, and fostering partnerships that drive meaningful transformation. Their AI Fellows program exemplifies their commitment to nurturing the next generation of healthcare AI founders by providing mentorship, business strategy development, and access to industry leaders[2][3][4][5].
Define Ventures operates at the intersection of healthcare and technology during a pivotal era marked by rapid innovation, demographic shifts like aging populations, and systemic pressures such as clinician shortages. Their timing is critical as AI moves from hype to strategic integration in healthcare, enabling new models of care and operational efficiencies. By fostering collaboration between startups and established healthcare entities, Define Ventures helps accelerate the adoption of transformative technologies. This positions them as a key catalyst in shaping the future healthcare ecosystem, influencing trends in digital health innovation, AI application, and value-based care delivery[2][4][7].
Looking ahead, Define Ventures is poised to deepen its influence by continuing to invest in AI-driven health technologies and expanding its support for founders who can navigate the complexities of healthcare innovation. Trends such as generative AI, personalized medicine, and holistic digital health platforms will likely shape their portfolio and strategic focus. Their ongoing commitment to partnership and leadership development suggests they will remain a vital force in defining healthcare’s next generation, helping startups not only survive but thrive in an evolving market landscape[4][5][6].
In sum, Define Ventures exemplifies a venture capital firm that is not just funding digital health startups but actively shaping the future of healthcare through deep expertise, strategic partnerships, and a technology-driven vision.
Define Ventures has more than 26 tracked investments across 23 companies. The latest tracked deal is $38.0M Series B in Luminai in April 2026.
